生長因子在傷口修復方面的作用機制 @

Growth factor interactions at the wound site.

A: regulation of fibroblast growth factor (FGF)7 at the wound site— hypothetical model.

Local hemorrhage causes extravasation of platelets and their release of PDGF and EGF. These mitogens stimulate FGF7 expression in fibroblasts. In addition, invading neutrophils and

macrophages secrete the proinflammatory cytokines IL-1 and TNF-β which then cause a further induction of FGF7 expression in fibroblasts. Finally, IL-1 and TGF-β derived from keratinocytes also stimulate FGF7

expression in fibroblasts.

B: regulation of VEGF expression at the wound site—hypothetical model.

Local hemorrhage causes extravasation of platelets and their release of TGF-β. Invading macrophages also secrete this growth factor, together with the proinflammatory cytokines IL-1 and TNF-β. These factors stimulate VEGF expression in keratinocytes and macrophages. In addition, FGF7 and hepatocyte growth factor (HGF) derived from fibroblasts as well as keratinocyte-derived TGF-β stimulate VEGF expression in the epidermis.

生長因子在傷口修復方面的作用機制

摘錄這一篇圖示說明在告訴大家,傷口修復或者表皮新生,事實上是一連串的體內生理反應所造成的,單一生長因子對皮膚組織新生在實驗結果上雖然是有效果,但是還是需要體內諸多狀況配合得宜才能達到預想中的效果!

從另一個角度來說,生長因子會引起細胞異常增生的理論,需要更多項的因素配合!這就是我只選擇單一表皮生長因子EGF而不用複合生長因子(多種生長因子)作為我們保濕復妍因子(時空膠囊)這個產品主要成分的理由---"多種生長因子混用可能導致細胞危險增生的機會比使用單一生長因子高很多"!!