保養品的過敏反應:發生機率/診斷/處理

這是2004年,一篇英國的研究報告摘要,大家再參考一下!

Am J Clin Dermatol. 2004;5(5):327-37.

Cosmetic allergy: incidence, diagnosis, and management

(保養品的過敏反應:發生機率/診斷/處理)

Orton DI, Wilkinson JD.

Environmental and Contact Dermatitis Unit, Department of Dermatology, Amersham Hospital, Amersham, Buckinghamshire, UK.

A recent epidemiologic survey in the UK revealed that 23% of women and 13.8% of men experience some sort of adverse reaction to a personal care product over the course of a year. Although most of these reactions may be due to subjective sensory irritation, various studies reveal that up to 10% of dermatologic patients who are patch tested are allergic to cosmetic products or their constituent ingredients. Causative products include deodorants and perfumes, skin care products, hair care products, and nail cosmetics. Allergic contact dermatitis mainly results from fragrance chemicals and preservatives. Recent work has suggested that additional fragrance chemicals may need to be tested in order to identify those patients 'missed' by the current fragrance mix; in particular, hydroxy-isohexyl-3-cyclohexene carboxaldehyde (HMPPC Lyral) has been singled out as an important sensitizing agent. The increased usage of natural fragrances and botanic extracts can also cause problems in their own right or through co-reactivity. The preservative methyldibromo glutaronitrile has also been recognized as an increasingly important sensitizer in Europe, which has led to the recent recommendation that it should be prohibited from 'leave-on' products until information on 'safe' consumer levels becomes available. Other emerging allergens include UV filters, tosylamide/formaldehyde resin, and nail acrylates.The diagnosis of cosmetic allergy should be confirmed with patch testing, including testing of 'whole' products, when necessary, and repeat open application tests can be used to confirm the relevance of reactions in cases of doubt.

本篇文章提到有23%的女性及13.8%的男性在一年內經歷了個人保養品的副作用!

我會摘錄這篇文章最重要的原因在於兩點:

1.很多人認為天然香精以及草本萃取的使用就不會產生敏感的問題,其實不然!雖然這類的成分產生敏感性的可能比較低,但是仍然會造成一些問題,尤其是在成分複雜度高的情況下(也就是所謂的co-reactivity效應)!

2.本篇文章也主張皮膚貼片敏感測試如果需要的話最好要包括全部的成分,這跟我所論述的是一樣的概念,因為成分越複雜,產生過敏的機會一定越高,而且上面所說的co-reactivity的情況也會增多!另外做皮膚貼片敏感測試的準確度也會減少!

大家可以好好思考一下!

Dr. Hsieh 2007/1/1 於高雄市