一篇EGF早期的臨床研究報告

這是一篇非常早期(1989)的臨床醫學研究論文摘要，它發表在美國新英格蘭雜誌。我們都知道美國的新英格蘭雜誌是全球有關臨床醫學研究的雜誌中，最著名的一本期刊。

在此我將這篇文章提出來主要有兩個意義:

1.    以往有許多的網友提出『單一的表皮生長因子EGF並沒有任何作用，而是需要所謂多重的生長因子才能得到良好的效果』，這篇文章就是要告訴大家，其實有許多的研究報告早就指出單一EGF的作用效果是OK的。

2.    表皮生長因子EGF在人體的醫學研究早就有許許多的報告完成，並非許多網路朋友所說的並未應用到人體上。

N Engl J Med. 1989 Jul 13;321(2):76-9.

Enhancement of wound healing by topical treatment with epidermal growth factor.

(局部使用表皮生長因子對傷口癒合的幫助)

Brown GL, Nanney LB, Griffen J, Cramer AB, Yancey JM, Curtsinger LJ 3rd, Holtzin L, Schultz GS, Jurkiewicz MJ, Lynch JB.

Department of Surgery, Emory University, Atlanta.

(美國亞特蘭大Emory大學一般外科)

Experimental studies in animals have demonstrated that the topical application of epidermal growth factor accelerates the rate of epidermal regeneration of partial-thickness wounds and second-degree burns. We conducted a prospective, randomized, double-blind clinical trial using skin-graft-donor sites to determine whether epidermal growth factor would accelerate the rate of epidermal regeneration in humans. Paired donor sites were created in 12 patients who required skin grafting for either burns or reconstructive surgery. One donor site from each patient was treated topically with silver sulfadiazine cream, and one was treated with silver sulfadiazine cream containing epidermal growth factor. The donor sites were photographed daily, and healing was measured with the use of planimetric analysis. The donor sites treated with silver sulfadiazine containing epidermal growth factor had an accelerated rate of epidermal regeneration in all 12 patients as compared with that in the paired donor sites treated with silver sulfadiazine alone. Treatment with epidermal growth factor significantly decreased the average length of time to 25 percent and 50 percent healing by approximately one day and that to 75 percent and 100 percent healing by approximately 1.5 days (P less than 0.02). Histologic evaluation of punch-biopsy specimens taken from the centers of donor sites three days after the onset of healing supported these results. We conclude that epidermal growth factor accelerates the rate of healing of partial-thickness skin wounds. Further studies are required to determine the clinical importance of this finding.

本篇文章開宗明義就指出在許多的動物實驗上，局部使用表皮生長因子EGF的確可以加速傷口(表皮層傷口及燒燙傷)上皮組織的增生。

結論中則提到在人體的應用上，局部外用表皮生長因子EGF對表皮層傷口的癒合確實有加速的作用。

另外，在此我要再次強調說明的是，肌膚保養並非在治療疾患，更不是要迅速的讓皮膚組織增生來癒合傷口；肌膚保養是一種長期漸進的肌膚改善方式，換句話說，是讓您的膚質與膚況在不傷害肌膚的安全的前提下，得到最好的照護與改善。

往後我將陸續的提出手上的一些醫學研究報告，讓大家對EGF能有更多的了解與認知，也希望能藉由此種模式，使得未來大家在選擇肌膚保養產品的時候能夠依循此種模式，對產品得到最大的最深入的了解，這對國內保養品領域的發展應該是一個正面的推力！

Dr. Hsieh 2007/1/4 於高雄市